Innovative nonprofit leaders and philanthropists have developed several effective social programs over the past decade. Despite this progress, even the most successful programs reach only a small fraction of those in need. Bridging this gap to reach transformative scale requires new strategies that extend beyond the boundaries of any single organization—new forms of collaboration within and across sectors, new platforms for learning and spreading what works, and different types of funding models. We seek to increase the number of problems being addressed at a population-level of scale.